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张和平+魏泓+徐健:肠道菌群可能引发乳腺炎

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    原标题:奶牛到小鼠的粪菌移植提示肠道微生物组是导致乳腺炎的一个原因

    ① 给无菌小鼠移植乳腺炎奶牛的粪便菌群,可引起小鼠乳腺炎症状,以及血清、脾脏和结肠中的炎症,而移植健康奶牛的粪菌无此作用;

    ② 补充干酪乳杆菌,可减轻移植患病奶牛粪菌的小鼠的乳腺炎症状;③ 益生菌未显著改变受体中失调的肠道菌群,但改变了菌群功能,与健康和乳腺炎菌群的均有区别;

    ④ 虽然奶牛与小鼠的乳腺炎症状一致,但二者肠道菌群中乳腺炎相关细菌或功能标志物的共性较少;

    ⑤ 健康与患病奶牛的肠道菌群差异,在受体小鼠中被放大。

Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis

DOI: 10.1186/s40168-018-0578-1

Abstract:

BACKGROUND Mastitis, which affects nearly all lactating mammals including human, is generally thought to be caused by local infection of the mammary glands. For treatment, antibiotics are commonly prescribed, which however are of concern in both treatment efficacy and neonate safety. Here, using bovine mastitis which is the most costly disease in the dairy industry as a model, we showed that intestinal microbiota alone can lead to mastitis.

RESULTS Fecal microbiota transplantation (FMT) from mastitis, but not healthy cows, to germ-free (GF) mice resulted in mastitis symptoms in mammary gland and inflammations in serum, spleen, and colon. Probiotic intake in parallel with FMT from diseased cows led to relieved mastitis symptoms in mice, by shifting the murine intestinal microbiota to a state that is functionally distinct from either healthy or diseased microbiota yet structurally similar to the latter. Despite conservation in mastitis symptoms, diseased cows and mice shared few mastitis-associated bacterial organismal or functional markers, suggesting striking divergence in mastitis-associated intestinal microbiota among lactating mammals. Moreover, an “amplification effect” of disease-health distinction in both microbiota structure and function was apparent during the cow-to-mouse FMT.

CONCLUSIONS Hence, dysbiosis of intestinal microbiota may be one cause of mastitis, and probiotics that restore intestinal microbiota function are an effective and safe strategy to treat mastitis.

First Authors:

Chen Ma,Zheng Sun,Benhua Zeng

Correspondence:

Jian Xu,Hong Wei,Heping Zhang

All Authors:

Chen Ma,Zheng Sun,Benhua Zeng,Shi Huang,Jie Zhao,Yong Zhang,Xiaoquan Su,Jian Xu,Hong Wei,Heping Zhang

2018-11-08Article


 
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