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益生菌辅助治疗通过调节肠道菌群缓解溃疡性结肠炎

过敏菌转发赠送活动优惠大大!
  1. 25名活动性UC患者随机分为2组,12名口服益生菌(含有干酪乳杆菌Zhang、植物乳杆菌P-8、动物双歧杆菌乳亚种V9),13名口服安慰剂,2组患者同时服用相同剂量的美沙拉嗪,干预12周;

  2. 益生菌组患者的UC疾病活动指数(UCDAI)降低显著高于安慰剂组,缓解率也显著升高(91.67% vs. 69.23%);

  3. 通过结肠镜检获取肠道粘膜菌群,益生菌可抑制菌群多样性及丰富度的减少,并增加戊糖片球菌等多种有益菌;

  4. 有益菌的相对丰度与UCDAI呈显著负相关。

  主编推荐语

  szx
  
  来自内蒙古农业大学的张和平团队与中日友好医院的周晓峰团队合作在Microbial Biotechnology上发表的一项随机双盲安慰剂对照试验结果,在25名活动性溃疡性结肠炎(UC)患者中发现,相比于单独使用美沙拉嗪治疗,美沙拉嗪+益生菌治疗12周后,可更有效地缓解UC症状,并显著提升缓解率,同时增加肠道粘膜菌群中的有益菌相对丰度。另外,有益菌相对丰度与UC疾病活动指数之间呈显著负相关,提示益生菌可通过调节肠道菌群以缓解UC。

  Microbial Biotechnology        [IF:5.328]
  Modulation of gut mucosal microbiota as a mechanism of probiotics‐based adjunctive therapy for ulcerative colitis
  调节肠道粘膜菌群作为基于益生菌的辅助疗法治疗溃疡性结肠炎的机制
  10.1111/1751-7915.13661
  09-23, Article
  Abstract:
  This was a pilot study aiming to evaluate the effects of probiotics as adjunctive treatment for ulcerative colitis (UC). Twenty‐five active patients with UC were assigned to the probiotic (n = 12) and placebo (n = 13) groups. The probiotic group received mesalazine (60 mg kg−1 day−1) and oral probiotics (containing Lactobacillus casei Zhang, Lactobacillus plantarum P‐8 and Bifidobacterium animalis subsp. lactis V9) twice daily for 12 weeks, while the placebo group received the same amounts of mesalazine and placebo. The clinical outcomes were assessed. The gut mucosal microbiota was profiled by PacBio single‐molecule, real‐time (SMRT) sequencing of the full‐length 16S rRNA of biopsy samples obtained by colonoscopy. A significantly greater magnitude of reduction was observed in the UC disease activity index (UCDAI) in the probiotic group compared with the placebo group (P = 0.043), accompanying by a higher remission rate (91.67% for probiotic‐receivers versus 69.23% for placebo‐receivers, P = 0.034). The probiotics could protect from diminishing of the microbiota diversity and richness. Moreover, the gut mucosal microbiota of the probiotic‐receivers had significantly more beneficial bacteria like Eubacterium ramulus (P < 0.05), Pediococcus pentosaceus (P < 0.05), Bacteroides fragilis (P = 0.02) and Weissella cibaria (P = 0.04). Additionally, the relative abundances of the beneficial bacteria correlated significantly but negatively with the UCDAI score, suggesting that the probiotics might alleviate UC symptoms by modulating the gut mucosal microbiota. Our research has provided new insights into the mechanism of symptom alleviation in UC by applying probiotic‐based adjunctive treatment.
First Authors:
Ping Chen,Haiyan Xu
Correspondence Authors:
XiaoFeng Zhou,Heping Zhang
All Authors:
Ping Chen,Haiyan Xu,Hai Tang,Feiyan Zhao,Chengcong Yang,Lai‐Yu Kwok,Chunli Cong,YanFang Wu,Wenyi Zhang,XiaoFeng Zhou,Heping Zhang
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